Bali Organix recognizes that many products in the market claim to offer health benefits and weightloss results that simply have no scientific evidence or clinical peer-reviewed studies. We would never claim our products offer health benefits that are not fully substantiated, so we have prepared a list of the evidence behind our claims:
Copy the details and search in Google for the full scientific trial results.
Roshan, H., Nikpayam, O., Sedaghat, M., & Sohrab, G. (2018). Effects of green coffee extract supplementation on anthropometric indices, glycaemic control, blood pressure, lipid profile, insulin resistance and appetite in patients with the metabolic syndrome: A randomised clinical trial. British Journal of Nutrition, 119(3), 250-258. doi:10.1017/S0007114517003439
- Takami, H, Nakamoto, M, Uemura, H, et al. (2013) Inverse correlation between coffee consumption and prevalence of metabolic syndrome: baseline survey of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study in Tokushima, Japan. J Epidemiol 23, 12–20.
- International Diabetes Federation (2006) The IDF consensus worldwide definition of the metabolic syndrome. https://www.idf.org/e-library/consensus-statements/60-idfconsensus-worldwide-definitionof-the-metabolic-syndrome.html (accessed November 2017).
- Razavi, BM & Hosseinzadeh, H (2017) Saffron: a promising natural medicine in the treatment of metabolic syndrome. J Sci Food Agric 97, 1679–1685.
- Santana-Galvez, J, Cisneros-Zevallos, L & Jacobo-Velazquez, DA (2017) Chlorogenic acid: recent advances on its dual role as a food additive and a nutraceutical against metabolic syndrome. Molecules 22, 358.
- Shang, F, Li, X & Jiang, X (2016) Coffee consumption and risk of the metabolic syndrome: a meta-analysis. Diabetes Metab 42, 80–87.
- Ahmed, GM, El-Ghamery, HE & Samy, MF (2013) Effect of green and degree of roasted Arabic coffee on hyperlipidemia and antioxidant status in diabetic rats. Adv J Food Sci Technol 5, 619–626.
- Meng, S, Cao, J, Feng, Q, et al. (2013) Roles of chlorogenic acid on regulating glucose and lipids metabolism: a review. Evid Based Complement Alternat Med 2013, 801457.
- Upadhyay, R & Mohan Rao, LJ (2013) An outlook on chlorogenic acids-occurrence, chemistry, technology, and biological activities. Crit Rev Food Sci Nutr 53, 968–984.
- Ludwig, IA, Mena, P, Calani, L, et al. (2014) Variations in caffeine and chlorogenic acid contents of coffees: what are we drinking? Food Funct 5, 1718–1726.
- Cho, AS, Jeon, SM, Kim, MJ, et al. (2010) Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice. Food Chem Toxicol 48, 937–943.
- Ong, KW, Hsu, A & Tan, BK (2013) Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation. Biochem Pharmacol 85, 1341–1351.
- Ma, Y, Gao, M & Liu, D (2015) Chlorogenic acid improves high fat diet-induced hepatic steatosis and insulin resistance in mice. Pharm Res 32, 1200–1209.
- Onakpoya, IJ, Spencer, EA, Thompson, MJ, et al. (2015) The effect of chlorogenic acid on blood pressure: a systematic review and meta-analysis of randomized clinical trials. J Hum Hypertens 29, 77–81.
- Mubarak, A, Bondonno, CP, Liu, AH, et al. (2012) Acute effects of chlorogenic acid on nitric oxide status, endothelial function, and blood pressure in healthy volunteers: a randomized trial. J Agric Food Chem 60, 9130–9136.
- Thom, E (2007) The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people. J Int Med Res 35, 900–908.
- Sarriá, B, Martínez-López, S, Sierra-Cinos, JL, et al. (2016) Regularly consuming a green/roasted coffee blend reduces the risk of metabolic syndrome. Eur J Nutr (Epublication ahead of print version 13 October 2016).
- Varghese, M, Ho, L, Wang, J, et al. (2014) Green coffee as a novel agent for Alzheimer’s disease prevention by attenuating diabetes. Transl Neurosci 5, 111–116.
- Li Kwok Cheong, JD, Croft, KD, Henry, PD, et al. (2014) Green coffee polyphenols do not attenuate features of the metabolic syndrome and improve endothelial function in mice fed a high fat diet. Arch Biochem Biophys 559, 46–52.
- Revuelta-Iniesta, R & Al-Dujaili, EA (2014) Consumption of green coffee reduces blood pressure and body composition by influencing 11beta-HSD1 enzyme activity in healthy individuals: a pilot crossover study using green and black coffee. Biomed Res Int 2014, 482704.
- Watanabe, T, Arai, Y, Mitsui, Y, et al. (2006) The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension. Clin Exp Hypertens 28, 439–449.
- Kozuma, K, Tsuchiya, S, Kohori, J, et al. (2005) Antihypertensive effect of green coffee bean extract on mildly hypertensive subjects. Hypertens Res 28, 711–718.
- Choi, BK, Park, SB, Lee, DR, et al. (2016) Green coffee bean extract improves obesity by decreasing body fat in high-fat diet-induced obese mice. Asian Pac J Trop Med 9, 635–643.
- Song, SJ, Choi, S & Park, T (2014) Decaffeinated green coffee bean extract attenuates diet-induced obesity and insulin resistance in mice. Evid Based Complement Alternat Med 2014, 718379.
- Ho, L, Varghese, M, Wang, J, et al. (2012) Dietary supplementation with decaffeinated green coffee improves diet-induced insulin resistance and brain energy metabolism in mice. Nutr Neurosci 15, 37–45.
- Dellalibera, O, Lemaire, B & Lafay, S (2006) Svetol®, green coffee extract, induces weight loss and increases the lean to fat mass ratio in volunteers with overweight problem. Phytotherapie 4, 194–197.
- Shimoda, H, Seki, E & Aitani, M (2006) Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice. BMC Complement Altern Med 6, 9.
- Blum, J, Lemaire, B & Lafay, S (2007) Effect of a green decaffeinated coffee extract on glycaemia: a pilot prospective clinical study. NutraFoods 6, 13–17.
- Ghaffarpour, M, Houshiar-Rad, A & Kianfar, H (1999) The Manual for Household Measures, Cooking Yields Factors and Edible Portion of Foods. Tehran: Nashre Olume Keshavarzy.
- Ainsworth, BE, Haskell, WL, Whitt, MC, et al. (2000) Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc 32, S498–S504.
- Wilson, MM, Thomas, DR, Rubenstein, LZ, et al. (2005) Appetite assessment: simple appetite questionnaire predicts weight loss in community-dwelling adults and nursing home residents. Am J Clin Nutr 82, 1074–1081
- Matthews, DR, Hosker, JP, Rudenski, AS, et al. (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28, 412–419.
- Ebrahimi, M, Ghayour-Mobarhan, M, Rezaiean, S, et al. (2009) Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity. Acta Cardiol 64, 321–327.
- Ong, KW, Hsu, A & Tan, BK (2012) Chlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation: a contributor to the beneficial effects of coffee on diabetes. PLOS ONE 7, e32718.
- Henry-Vitrac, C, Ibarra, A, Roller, M, et al. (2010) Contribution of chlorogenic acids to the inhibition of human hepatic glucose-6-phosphatase activity in vitro by Svetol, a standardized decaffeinated green coffee extract. J Agric Food Chem 58, 4141–4144.
- Jin, S, Chang, C, Zhang, L, et al. (2015) Chlorogenic acid improves late diabetes through adiponectin receptor signaling pathways in db/db mice. PLOS ONE 10, e0120842.
- Shimoda H, Seki E and Aitani M. Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice. BMC Complementary and Alternative Medicine 2006;6:9
- Y. Wang, L. Huang, Y. L. Zhong, et al., “Effects of three kinds of dietary polyphenolyphenols on glucose and lipid metabolism in chemical-induced diabetic rats,” Acta Nutrimenta Sinica, vol. 34, no. 6, pp. 572–575, 2012.
- M. F. McCarty, “A chlorogenic acid-induced increase in GLP-1 production may mediate the impact of heavy coffee consumption on diabetes risk,” Medical Hypotheses, vol. 64, no. 4, pp. 848–853, 2005.
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