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Scientific References

Bali Organix recognizes that many products in the market claim to offer health benefits and weightloss results that simply have no scientific evidence or clinical peer-reviewed studies. We would never claim our products offer health benefits that are not fully substantiated, so we have prepared a list of the evidence behind our claims:




Scientic Trials

Copy the details and search in Google for the full scientific trial results.

  1. Roshan, H., Nikpayam, O., Sedaghat, M., & Sohrab, G. (2018). Effects of green coffee extract supplementation on anthropometric indices, glycaemic control, blood pressure, lipid profile, insulin resistance and appetite in patients with the metabolic syndrome: A randomised clinical trial. British Journal of Nutrition, 119(3), 250-258. doi:10.1017/S0007114517003439       
  1. Takami, H, Nakamoto, M, Uemura, H, et al. (2013) Inverse correlation between coffee consumption and prevalence of metabolic syndrome: baseline survey of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study in Tokushima, Japan. J Epidemiol 23, 12–20.         
  1. International Diabetes Federation (2006) The IDF consensus worldwide definition of the metabolic syndrome. (accessed November 2017).
  1. Razavi, BM & Hosseinzadeh, H (2017) Saffron: a promising natural medicine in the treatment of metabolic syndrome. J Sci Food Agric 97, 1679–1685.         
  1. Santana-Galvez, J, Cisneros-Zevallos, L & Jacobo-Velazquez, DA (2017) Chlorogenic acid: recent advances on its dual role as a food additive and a nutraceutical against metabolic syndrome. Molecules 22, 358.   
  1. Shang, F, Li, X & Jiang, X (2016) Coffee consumption and risk of the metabolic syndrome: a meta-analysis. Diabetes Metab 42, 80–87.         
  1. Ahmed, GM, El-Ghamery, HE & Samy, MF (2013) Effect of green and degree of roasted Arabic coffee on hyperlipidemia and antioxidant status in diabetic rats. Adv J Food Sci Technol 5, 619–626.   
  1. Meng, S, Cao, J, Feng, Q, et al. (2013) Roles of chlorogenic acid on regulating glucose and lipids metabolism: a review. Evid Based Complement Alternat Med 2013, 801457.         
  1. Upadhyay, R & Mohan Rao, LJ (2013) An outlook on chlorogenic acids-occurrence, chemistry, technology, and biological activities. Crit Rev Food Sci Nutr 53, 968–984.         
  1. Ludwig, IA, Mena, P, Calani, L, et al. (2014) Variations in caffeine and chlorogenic acid contents of coffees: what are we drinking? Food Funct 5, 1718–1726.         
  1. Cho, AS, Jeon, SM, Kim, MJ, et al. (2010) Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice. Food Chem Toxicol 48, 937–943.         
  1. Ong, KW, Hsu, A & Tan, BK (2013) Anti-diabetic and anti-lipidemic effects of chlorogenic acid are mediated by ampk activation. Biochem Pharmacol 85, 1341–1351.         
  1. Ma, Y, Gao, M & Liu, D (2015) Chlorogenic acid improves high fat diet-induced hepatic steatosis and insulin resistance in mice. Pharm Res 32, 1200–1209.         
  1. Onakpoya, IJ, Spencer, EA, Thompson, MJ, et al. (2015) The effect of chlorogenic acid on blood pressure: a systematic review and meta-analysis of randomized clinical trials. J Hum Hypertens 29, 77–81.         
  1. Mubarak, A, Bondonno, CP, Liu, AH, et al. (2012) Acute effects of chlorogenic acid on nitric oxide status, endothelial function, and blood pressure in healthy volunteers: a randomized trial. J Agric Food Chem 60, 9130–9136.         
  1. Thom, E (2007) The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people. J Int Med Res 35, 900–908.         
  1. Sarriá, B, Martínez-López, S, Sierra-Cinos, JL, et al. (2016) Regularly consuming a green/roasted coffee blend reduces the risk of metabolic syndrome. Eur J Nutr (Epublication ahead of print version 13 October 2016).   
  1. Varghese, M, Ho, L, Wang, J, et al. (2014) Green coffee as a novel agent for Alzheimer’s disease prevention by attenuating diabetes. Transl Neurosci 5, 111–116.   
  1. Li Kwok Cheong, JD, Croft, KD, Henry, PD, et al. (2014) Green coffee polyphenols do not attenuate features of the metabolic syndrome and improve endothelial function in mice fed a high fat diet. Arch Biochem Biophys 559, 46–52.  
  1. Revuelta-Iniesta, R & Al-Dujaili, EA (2014) Consumption of green coffee reduces blood pressure and body composition by influencing 11beta-HSD1 enzyme activity in healthy individuals: a pilot crossover study using green and black coffee. Biomed Res Int 2014, 482704.         
  1. Watanabe, T, Arai, Y, Mitsui, Y, et al. (2006) The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension. Clin Exp Hypertens 28, 439–449.         
  1. Kozuma, K, Tsuchiya, S, Kohori, J, et al. (2005) Antihypertensive effect of green coffee bean extract on mildly hypertensive subjects. Hypertens Res 28, 711–718.         
  1. Choi, BK, Park, SB, Lee, DR, et al. (2016) Green coffee bean extract improves obesity by decreasing body fat in high-fat diet-induced obese mice. Asian Pac J Trop Med 9, 635–643.         
  1. Song, SJ, Choi, S & Park, T (2014) Decaffeinated green coffee bean extract attenuates diet-induced obesity and insulin resistance in mice. Evid Based Complement Alternat Med 2014, 718379.         
  1. Ho, L, Varghese, M, Wang, J, et al. (2012) Dietary supplementation with decaffeinated green coffee improves diet-induced insulin resistance and brain energy metabolism in mice. Nutr Neurosci 15, 37–45.         
  1. Dellalibera, O, Lemaire, B & Lafay, S (2006) Svetol®, green coffee extract, induces weight loss and increases the lean to fat mass ratio in volunteers with overweight problem. Phytotherapie 4, 194–197. 
  1. Shimoda, H, Seki, E & Aitani, M (2006) Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice. BMC Complement Altern Med 6, 9.         
  1. Blum, J, Lemaire, B & Lafay, S (2007) Effect of a green decaffeinated coffee extract on glycaemia: a pilot prospective clinical study. NutraFoods 6, 13–17.
  1. Ghaffarpour, M, Houshiar-Rad, A & Kianfar, H (1999) The Manual for Household Measures, Cooking Yields Factors and Edible Portion of Foods. Tehran: Nashre Olume Keshavarzy.
  1. Ainsworth, BE, Haskell, WL, Whitt, MC, et al. (2000) Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc 32, S498–S504.         
  1. Wilson, MM, Thomas, DR, Rubenstein, LZ, et al. (2005) Appetite assessment: simple appetite questionnaire predicts weight loss in community-dwelling adults and nursing home residents. Am J Clin Nutr 82, 1074–1081
  1. Matthews, DR, Hosker, JP, Rudenski, AS, et al. (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28, 412–419.         
  1. Ebrahimi, M, Ghayour-Mobarhan, M, Rezaiean, S, et al. (2009) Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity. Acta Cardiol 64, 321–327.         
  1. Ong, KW, Hsu, A & Tan, BK (2012) Chlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation: a contributor to the beneficial effects of coffee on diabetes. PLOS ONE 7, e32718.         
  1. Henry-Vitrac, C, Ibarra, A, Roller, M, et al. (2010) Contribution of chlorogenic acids to the inhibition of human hepatic glucose-6-phosphatase activity in vitro by Svetol, a standardized decaffeinated green coffee extract. J Agric Food Chem 58, 4141–4144.         
  1. Jin, S, Chang, C, Zhang, L, et al. (2015) Chlorogenic acid improves late diabetes through adiponectin receptor signaling pathways in db/db mice. PLOS ONE 10, e0120842.
  1. Shimoda H, Seki E and Aitani M. Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice. BMC Complementary and Alternative Medicine 2006;6:9
  1. Y. Wang, L. Huang, Y. L. Zhong, et al., “Effects of three kinds of dietary polyphenolyphenols on glucose and lipid metabolism in chemical-induced diabetic rats,” Acta Nutrimenta Sinica, vol. 34, no. 6, pp. 572–575, 2012.
  1. M. F. McCarty, “A chlorogenic acid-induced increase in GLP-1 production may mediate the impact of heavy coffee consumption on diabetes risk,” Medical Hypotheses, vol. 64, no. 4, pp. 848–853, 2005.

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